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Diastolic blood pressure reductions tend to be smaller, reinforcing the importance of continuing guideline-directed antihypertensive treatment

In addition, chimeric GLP-2 whose C-terminal fragment (residues 2033) was replaced with that of GLP-1 displayed a 17-fold potency reduction in GLP-2R signaling but successfully elicited GLP-1R-mediated cAMP accumulation (Fig