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doi:10.1073/PNAS.1611576114/-/DCSUPPLEMENTAL 7
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"FDA Approves First Medication for Obstructive Sleep Apnea." Fras JP, et al
It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects
McLeod provided Banting with laboratory facilities, some experimental dogs and the assistance of Charles Best, a research student
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