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A November 2023 study in the New England Journal of Medicine found that semaglutide reduced the risk of major cardiovascular events including heart attack, stroke and cardiovascular death by about 20% in overweight or obese adults who already have established cardiovascular disease but not diabetes
Journal of pain research, 12, 13411351
11 However, the cost effectiveness of retreatment remains uncertain
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NICE guidance recommends at least 150 minutes of moderate-intensity aerobic activity per week, following a Mediterranean-style diet, reducing refined carbohydrates and added sugars, and limiting alcohol consumption in line with UK Chief Medical Officers' guidance
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