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The Wegovy SmPC advises that semaglutide should be discontinued if pancreatitis is suspected Signs of gallbladder disease including right upper quadrant pain, fever, or jaundice, as GLP-1 receptor agonists and weight loss can increase the risk of gallstones Routine GP consultation is advisable for: Gastrointestinal symptoms persisting beyond 46 weeks without improvement Symptoms significantly impacting quality of life or nutritional intake Unexplained weight loss exceeding expected therapeutic effects New onset of symptoms differing from initial side effects Concerns about symptom severity or medication tolerability NICE guidance on obesity management (TA875) emphasises the importance of regular monitoring during pharmacological weight management interventions
The encapsulation efficiency of DNA into the LNP was determined by the Picogreen assay (Thermo Ficher Scientific) following the manufacturers protocol
R., Bain, S
Some patients use medication long-term under supervision to maintain metabolic health
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