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This is the first study to prove it using human tissue

Calcium Gluconate: Essential for bone strength, nerve signaling, and muscle contraction

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Luo et al., 2018)

Regardless of the specific protein/mechanism compromised, we believe that HSV-1-induced accumulation of DSBs in neuronal genome might induce neurodegeneration through different pathways (i.e., p53-mediated apoptosis, autophagy deficiency and cell cycle re-entry), as observed in AD (Roos and Kaina, 2006