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A significant translational barrier for these metal-based (Mn, Cu) innate immune activators is the potential for long-term heavy metal toxicity
"It made things harder for people who were already in a hard spot," Lampkin said
This leads to epigenetic reprogramming of the transcriptome, resulting in an enhanced expression of autophagy-related genes in the context of a general silencing of many other genes 29
140 YangG.GongC.ZhengX.HuF.LiuJ.WangT.et al (2023)
Subsequently, Matei et al
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