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It's generally advised against in individuals with a personal or family history of medullary thyroid carcinoma or in those with Multiple Endocrine Neoplasia syndrome type 2

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Reminder: These distinctions come from animal data and anecdotal use, not clinical trials in women

Retatrutide's known side effect profile from trials includes nausea, vomiting, diarrhoea, decreased appetite, and injection-site reactions effects consistent with other GLP-1-based therapies

In general, it may take a few weeks to a couple of months for your body to adapt to the medication and for you to notice its effects on managing your diabetes