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Circu ML, Stringer S, Rhoads CA, Moyer MP, Aw TY
In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
It acts as a crucial electron donor, sacrificing its own electrons to stabilize free radicals before they can attack the mitochondrial lipid membranes
Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain
Thats one of the nice things about it: you can run it alongside pretty much anything without worrying about hormonal complications
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