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30 Relationship of S-adenosyl-L-Methionine and Glutathione The metabolism of GSH and S-adenosyl-L-methionine (SAM) are closely linked, as the liver forms GSH as a product of SAM metabolism (Figure 4)

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In the D-Gal + FOXO4-DRI group, mice also received D-galactose injections and, after 4 weeks, were given intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days for 4 weeks, followed by tissue collection

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