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Liraglutide also has antidepressant effects, as seen in many patients with neurodegenerative diseases, by preventing the loss of insulin receptors (28)
Targeted neurotherapeutics face a challenge in penetrating the blood brain barrier (BBB) [14-16]
The most notable is its capacity for substantial weight reduction, which may in turn confer downstream benefits including: Improved glycaemic control in individuals with type 2 diabetes Reduced cardiovascular risk factors such as hypertension and dyslipidaemia Potential improvement in hepatic steatosis , given the glucagon receptor component's proposed role in hepatic fat metabolism Possible improvements in physical function and quality of life associated with significant weight loss though these outcomes have not yet been formally established for retatrutide and require confirmation in Phase 3 trials As with all medicines in this class, retatrutide carries a recognised side effect profile
Yet, a deficiency exists in as many as 43% of older adults (4)
