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Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord

Wrist Circles: Slowly rotate wrist in circles, 10 each direction, 3 times daily Forearm Stretch: Extend arm, gently pull fingers back, hold 30 seconds Ball Squeeze (light): Gentle squeezes with soft stress ball, 10 reps, 2 times daily Supination/Pronation: Rotate forearm palm-up to palm-down, 15 reps Progressive Loading Phase (Weeks 3-6) As pain decreases and function improves, gradually introduce more challenging exercises

Likewise, angiogenesis plays a critical role in tumor growth, invasion and metastasis (Semela and Dufour, 2004)

13 (12), e238315