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Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, et al

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The mechanistic rationale is sound

In the case of chronic hyponatremia, treatment is variable: when sodium is 120129 mEq/L and the patient is mildly symptomatic or asymptomatic, it is sufficient to discontinue any drugs potentially causing hyponatremia, manage the underlying cause of low sodium, and limit oral or intravenous intake of water

Currently, several drugs are used to treat obesity, but their efficacy is modest