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96 Studies have shown that this process is dependent on intracellular complement component (C) 5aR1 signaling, where C5a binds to receptors on the mitochondria, triggering ROS production and providing one of the necessary activation signals for inflammasome assembly and IL-1 secretion, especially in response to sterile inflammation induced by cholesterol crystal exposure
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Serious Complications (Very Rare): Extremely rare but possible severe side effects can include congestive heart failure in individuals with certain heart conditions, or polycythemia vera (a blood disorder)
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