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3.Which tissues have high PPP activity
Metabolic pathways requiring thiamin pyrophosphate (TPP) The figure shows the various enzymes requiring TPP as a cofactor: In the cytosol, TPP is required for transketolase, which converts ribose 5-phosphate in the pentose phosphate cycle to glyceraldehyde 3-phosphate, which is converted to pyruvate in glycolysis
Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice
doi: 10.1002/jcb.20772 116 InesiG
The combination of variants linked to a slightly increased risk of liver damage could add together to increase the risk more significantly
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