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These large-scale studies have generally demonstrated favourable cardiovascular profiles, with some agents showing significant reductions in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and established cardiovascular disease
The ECD of GCGR, on the other hand, is in an extended conformation with the -sheet module covering the orthosteric TMD pocket and the inhibitory mAb1 engaging the orthosteric ECD-binding site directly
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Notably, recent evidence from a comprehensive review highlights that GLP-1RAs promote myelinogenesis and myelin maintenance, with their beneficial effects potentially mediated through PI3K/AKT pathway activation [263]
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