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If the mitochondrial transport system becomes a bottleneck, if there is not enough carnitine to shuttle all those mobilized fatty acids into the mitochondria for burning, then some of that fat may not get oxidized efficiently

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Clinical trials are ongoing for several of these compounds, and the regulatory landscape continues evolving

This was due to the fact that they ushered in a new era in obesity, helping to reshape attitudes to the condition and how it is treated