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The medication was first developed by Novo Nordisk and has received multiple FDA approvals

The IGB leads to weight reduction by mechanically obstructing gastric volume and stimulating satiety via mechanoreceptors [15]

This dual mechanism results in increased insulin production, decreased glucagon secretion, reduced appetite and energy intake, delayed gastric emptying, and significant weight loss in clinical trials compared to placebo

How does it Compare to Other Weight Management Peptides

To further identify the specific HDAC isoform that was involved in regulating GLP-1R expression, isoform-specific HDAC inhibitors were used