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At the 12mg maintenance dose, approximately 21% of participants reported constipation

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The major advantage of this approach is that small molecules have a considerable higher bioavailability compared to antibodies, dominant-negative receptors and antisense oligonucleotides

Presented for research literature review only Xiong S et al

The amino acid residues that make up the H-site are involved in recognizing and binding various exogenous and endogenous compounds and positioning their electrophilic centers for attack by the nucleophilic GSH