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While everyone's heard of GLP-1 agonists like semaglutide and tirzepatide, the amylin pathway remains relatively obscure despite producing comparable weight loss through an entirely different mechanism
However, except for the use of angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB) agents in chronic kidney disease, this is largely a pragmatic rather than evidence-based approach [52]
When you lose weight: Your heart doesnt have to work as hard Your body releases less of the hormones that raise blood pressure Your blood vessels can relax more easily Your kidneys work better Studies show that people on higher doses of GLP-1 medications (like semaglutide 2.4 mg or tirzepatide 15 mg) can lose 15% to 21% of their body weight
Cardio like walking, biking, or swimming is great for your heart and your overall health
Eli Lilly's Zepbound and Mounjaro continue to gain market share, eroding Novo Nordisk's early first-mover advantage
