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(6) neurotrophic agents offer the ability to facilitate synaptogenesis, neurogenesis and neuroprotection thus greater research attention must be directed toward creating small molecule analogs designed to penetrate the BBB and activate these brain systems

250,251,252 UA induced inflammation and relative mechanism Uric acid signaling triggers the activation of several transcription factors, such as NF-B or AP-1, through the activation of MAPK p38 and ERK pathways, resulting in the production of reactive oxygen species (ROS) under the conditions of hyperuricemia

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Vukusic D et al