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This additional receptor activation allows researchers to investigate whether triple-pathway modulation produces different metabolic outcomes compared to dual-agonist compounds

Missing metabolite values were imputed by replacement with half the minimum value for each metabolite in all samples

Treatments that decrease the liberation of glutamate from the glutathione cycle lead to decreased intracellular glutamate, whereas decreasing utilization of glutamate or glutathione synthesis increases it (16)

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Understanding the differences in dosage and regulatory uses between these medications is crucial for achieving the desired outcomes