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Compared with LIR once a day, once weekly subcutaneous injection of DUL similarly lowers body weight: 2.90 kg (-3.61 kg for LIR) after 26 weeks of treatment (109)

However, the efficacy of GLP-1R agonists in biopsy-proven NASH patients varies, suggesting that the expression levels of GLP-1R may be different in these patients

Another significant aspect of IGF-1 LR3s impact on muscle growth is its ability to inhibit protein breakdown

However, these effects are attenuated by PKA inhibitors or dominant-negative Epac overexpression [23, 25]

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