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We also observed that mean enrichment of a substrate decreases monotonically with increasing Hamming distance to procaspase-1, consistent with our hypothesis that cleavage activity on single-residue substitutions is predictive of cleavage activity on higher-order combinations of substitutions (Supplementary Fig

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Researchers at the University of Pennsylvania analyzed health records from roughly 12,004 adults with Type 2 diabetes who started taking GLP-1 medications between 2019 and 2024, comparing them with tens of thousands of other patients using two other diabetes drugs, SGLT-2 inhibitors and DPP-4 inhibitors

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