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[114] This functionality is lost in vitamin B 12 deficiency, and can be measured clinically as an increased serum methylmalonic acid (MMA) concentration

Appetite and food reward 3-arm Phase 1 tirzepatide vs liraglutide 3.0 mg vs placebo: measured lunch intake fell 524.6 kcal vs placebo by week 3 (about 72% of that difference remained at week 6), with craving and hedonic-hunger reductions exceeding liraglutide

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