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We show (i) that PfGrx-catalyzed redox reactions outcompete uncatalyzed reactions between roGFP2 and GSH or GSSG by several orders of magnitude, (ii) that the PfGrx-catalyzed reduction and oxidation of roGFP2 occur via a mono- and not a dithiol mechanism, and (iii) that the reduction of roGFP2(S 2 ) as a model non-glutathione disulfide substrate most likely involves a rate-limiting glutathionylation in a ternary complex with a GSH molecule that is activated at the 1st glutathione-interaction site of PfGrx

Osteoarthritis (OA) Osteoarthritis causes pain and stiffness due to both wear and tear and inflammation

Understanding the Connection Between Diabetes and Kidney Disease Kidney disease, particularly diabetic nephropathy , is a common complication of diabetes

Bansal, V

29 (2 Suppl): S38S51