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Efpeglenatide Efpeglenatide is a novel, long-acting GLP-1 receptor agonist developed by Hanmi Pharmaceuticals (South Korea) utilizing the proprietary LAPSCOVERY (Long-Acting Protein/Peptide Discovery) technology platform

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GLUCURONIDATION SAFE PATHWAY (UGT1A6 enzyme) 50-60% of acetaminophen in healthy non-pregnant adults Attaches glucuronic acid to make it water-soluble for urinary excretion Safe, non-toxic pathway INCREASES during pregnancy: 6% in first trimester, rising to 19% by third trimester[] Severely underdeveloped in fetuses/newborns 2

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