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Oral semaglutide has been studied in PIONEER 6 (designed as a non-inferiority trials), with a mean follow-up of 1.3 years and positive results for the primary endpoint: the MACE rate was reduced by 21% but did not achieve statistically significant differences
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An K, Deng X, Chi H, Zhang Y, Li Y, Cheng M, Ni Z, Yang Z, Wang C, Chen J, et al
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Intramuscular injections may feel slightly more noticeable since the needle goes deeper into the muscle, but using proper technique and following your providers instructions can make the process more comfortable
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