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GLP-1RAs, which are antidiabetic drugs, improve NAFLD and CVD in patients with type 2 diabetes mellitus by activating AMPK and SIRT6, key regulators of lipid, glucose, and cholesterol metabolism pathways [2326]
11 These include reductions in blood pressure, blood lipids, and inflammation, as well as direct effects on the heart muscle and blood vessels
This could diminish the unique advantage retatrutide holds over dual-agonists like tirzepatide
One question for future research, Sinaiko said, is how physicians respond when patients dont pick up needed medications, suggesting, for example, a switch to lower-cost drugs
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