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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl

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This growing body of evidence is what led Relive Health centers nationwide to offer NAD+ therapy with 5-Amino-1MQ, especially for adults over 40, whose NAD+ levels have already declined by up to 50% or more