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doi: 10.1016/j.endien.2024.03.012
Indeed, acute elevated peripheral insulin levels may increase insulin in cerebrospinal fluid, whereas, chronic peripheral hyperinsulinemia (such as insulin resistance or T2DM) may downregulate insulin receptors of the BBB, impair brain insulin uptake, and ultimately lead to learning, memory, and cognitive deficits (14, 52)
Table 3 shows the symptoms most likely to be long-lasting
Courreges JP, Vilsbll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O et al
This selectivity makes ipamorelin a valuable research tool for investigating GH secretion pathways independently of hypothalamic-pituitary-adrenal (HPA) axis activation
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