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It is reported that pathways based on TNF- regulate PAF, and TNF- antagonists inhibit platelet activation in active patients with RA (171)

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Endosomal escape and intracellular delivery Efficient intracellular delivery remains a significant challenge in the development of GLP-1R-targeted nanomedicines, particularly for nucleic acid cargos such as small interfering RNA (siRNA) and mRNA that require cytosolic access to exert their therapeutic effects