The cytokines TNF and IFN promote the accumulation of zinc in the phagosome of Mycobacterium avium-infected mouse macrophages, and phagosomal zinc levels increase over time in response to infection with Mycobacterium tuberculosis
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doi: 10.1093/nar/gkae973 Summary Keywords atheroscelrosis, cholesterol metabolism, acetyl-L-carnitine (ALC), SREBP2, HMGCR Citation Xing J, Du Z, Li F, Wang Y, Zhang Z, Gao X, Han L, Sun X, Sun H, Du Y, Hu C, Yu H and Qin Y (2024) Acetyl-L-carnitine ameliorates atherosclerosis in LDLR / mice by modulating cholesterol metabolism through SREBP2-dependent cholesterol biosynthesis
In this inflamed state, the body's natural stores of L-Carnitine are rapidly depleted as the compound is consumed in an attempt to buffer the oxidative stress and clear toxic metabolic byproducts from the struggling cells
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