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human C-cells express substantially lower levels of these same receptors Downstream signaling: Cellular responses differ between species C-cell biology: Rodent C-cells are inherently more prone to proliferation than human C-cells What the Warning Is, and Is Not Does advise against use in MTC/MEN2 patients Does NOT prove GLP-1 RAs causes MTC in humans whatsoever Does NOT apply to differentiated thyroid cancers of any type in any way In Summary: The warning exists because rodents developed C-cell tumors

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Presented for research literature review only Mathew J et al

Temperature is not the only threat