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Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation

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Endogenous melatonin secretion each night essentially acts as a temporal synchronizing signal that helps keep peripheral clocks in phase with the central SCN clock during the rest period

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The two primary pathways activated are the PI3K/Akt/mTOR pathway and the MAPK pathway