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Reported risks include pain, tenderness, bruising, or bleeding at the injection site
As for challenges exclusive to ECB, the most significant case is that Clostridium species possess extremely active Restriction and Modification (RM) system acting as an immune system to prevents genetic transfers between different species and phage invasions, which makes the Clostridium species one of the most difficult organisms to transform [107]
In SURMOUNT trials, tirzepatide 10 mg achieved average weight loss of 22% body weight, compared to 16% for semaglutide 2.4 mg in similar populations
Patients with certain genetic variants may respond effectively to lower doses, while others may require higher doses to achieve the same weight loss benefits
Histopathological evidence supports these proposed mechanisms
