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Some inherited metabolic disorders (pyridoxine-dependent conditions) may require very large daily doses
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Refrigeration at 4 C (39 F) extends shelf stability and is recommended for long-term storage
Biochemically, the cobalt center can take part in both two-electron and one-electron reductive processes to access the "reduced" (B 12r , +2 oxidation state) and "super-reduced" (B 12s , +1 oxidation state) forms
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