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Similar to previous protocol, we carried out tandem affinity purification and analyzed the protein complexes using negative stain electron microscopy, which exhibits a comparable dimeric architecture (Supplementary Fig
Drug Design, Development and Therapy, 18, 125138.
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Sequence comparison among endogenous hormones, approved drugs and triple agonists revealed that the peptide sequence is conserved in the N-terminal region (residues 49), with variations primarily occurring in the middle region (residues 1021) (Fig
