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Emerging multi-omics and metagenomic studies show that the gut microbial communities have influence on central processes through microbial metabolites, particularly SCFAs, tryptophan catabolites, and bile acid derivatives, which regulate microglial maturing, Treg/Th17 balance, and vagal nerve signaling [19]
Another study suggested that DNA damage in adipocytes can disturb secretory function and adipocyte metabolism and activate the p53 signaling pathway, inducing adipose tissue inflammation and insulin resistance
Drew Timmermans: Yes, that is
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