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Semaglutides mechanism of action, which involves slowing down gastric emptying and altering gut motility, may inadvertently affect the guts microbial balance
Commensal bacteria make GPCR ligands that mimic human signalling molecules
Genes Cells 24 , 436448 (2019)
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The increased -MSH activates the melanocortin four receptor (MC4R) (140), which in turn mobilizes the sympathetic nervous system, inhibits insulin secretion, enhances hepatic insulin sensitivity (141), and suppresses appetite by modulating NPY/AgRP neurons that promote insulin (142)
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