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Previous studies demonstrated that Ex-4 inhibits breast cancer cell proliferation through NF-B suppression, although significant apoptosis induction was not observed [55]

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Discussion Our data suggests that physiological (picomolar) concentrations of GLP-1 exert their glucagonostatic effects via mechanisms that are (at least in part) intrinsic to the glucagon-secreting -cells and that are independent of paracrine effects from the neighboring islet cells

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