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Survodutide, a GLP-1/glucagon dual agonist, is in phase 3
demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)
This generates a proton gradient that powers ATP synthase to produce ATP
Autophagy in axonal degeneration in glaucomatous optic neuropathy
doi: 10.1080/1040841X.2021.1902940 528 ShuklaVSinghSVermaSVermaSRizviAAAbbasM
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