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Exposure to various chemical compounds can also induce epigenetic changes that modulate the immune system and result in the facilitated development of certain diseases [1, 2, 37]

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While the spheroids treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere majorly consisted of living cells, the spheroids treated with NP4 in a 1% O 2 atmosphere consisted of dead cells (Fig