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Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)

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However, the balance between type I, II, and III cells was not affected

Where GHRP-2 offers potency at the cost of a broader hormonal footprint, ipamorelin trades a slice of the ghrelin-like breadth for a cleaner, GH-focused signal

The use of ultrasound is justified, therefore, as it is a non-invasive, inexpensive, accessible, and widely used method to assess the presence of NAFLD in children