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Klotho is expressed in vascular cells, and CKD is associated with a deficiency of vascular Klotho (Lim et al., 2012)

If retatrutide demonstrates a substantial benefit over alternative therapies, the FDA has the ability to provide priority review, which shortens the standard 10-month review to 6 months

Drug interactions with birth control can also go the other way, meaning that the hormones affect how the medicine works

The most common side effects are nausea, constipation, or other gastrointestinal discomfort

GLP-1 receptor agonists can be effective for people with hypothyroidism, particularly when thyroid function is optimised with levothyroxine