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In vitro and in MIA induced murine OA, the system promoted macrophage polarization from M1 to M2, reduced proinflammatory cytokines, shifted the joint milieu toward an anti-inflammatory state, preserved chondrocyte metabolic homeostasis, and supported BMSC chondrogenic differentiation (Figure 2D)

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While dieting alone may not always work, incorporating medications like Semiglutide can be a valuable toolif used correctly and under supervision

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