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Energy homeostasis involves the balanced use of lipid, glucose and protein substrates ( Reference Li, Li and Qin 27 , Reference Trevisan, Nosadini and Avogaro 77 , Reference Solini, Bonora and Bonadonna 78 )

SLC7A11 is a critical regulatory target involved in VRK2 regulating the GSH metabolic synthesis pathway Aforementioned data indicated that VRK2-deficient PC cells are vulnerable to GSH inhibition, this prompts us to explore the link between VRK2 and GSH metabolic synthesis pathway

2.1.2 ROS responsive hydrogels Reactive oxygen species (ROS) act as key secondary messengers that activate multiple transcription factors and amplify inflammatory responses (Manoharan et al., 2024)

Molecules , 16 (3), 20322052

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