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Global disruption of Gclm results in mice (GCLM knockout) that have 15% of hepatic GSH levels seen in wild-type mice 16
Physiological Reviews
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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later
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