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People with active cancers, untreated pituitary disorders, or certain metabolic conditions should avoid it unless specifically cleared by a medical provider (Mayo Clinic, 2024)
Patients with pre-existing diabetic retinopathy should be monitored closely, as rapid improvement in blood glucose control may temporarily worsen retinopathy
For microdosing, patients should be educated enough to follow and understand complex dosing instructions
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In the body-composition subgroup, total fat mass fell 19.3% while lean body mass fell 9.7%, and lean mass as a proportion of total body mass actually rose by 3.0 percentage points
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