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It is important to note that while GLP-1RAs have demonstrated CV safety, not all result in an actual reduction in CV adverse events, such as exenatide QW and lixisenatide, both of which were reported to be non-inferior to placebo for MACE [22, 23]

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Therefore, a lower dose of insulin or insulin secretagogue may be required to minimize the risk of hypoglycemia when these agents are used in combination with FARXIGA [see DRUG INTERACTIONS ]

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It boosts the synthesis of collagen, elastin, glycosaminoglycans, and other structural proteins that maintain firmness and elasticity