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Adverse Reactions in Patients for Weight Reduction and Long-Term Maintenance Pool of Placebo-Controlled Weight Reduction Trials in Adults with Obesity or Overweight, with or without Type 2 Diabetes (Study 1 and Study 2) ZEPBOUND was evaluated for safety in a pool of two randomized, double-blind, placebo-controlled trials that included 2,519 adult patients with obesity or overweight treated with ZEPBOUND for up to 72 weeks and a 4-week off drug follow-up period (Study 1 and Study 2) [see Clinical Studies (14.1)]
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Thus, careful monitoring during the first weeks of GLP-1 therapy is critical
Gamma-aminobutyric acid (GABA) GABA is an inhibitory neurotransmitter, turning down the rate of electrical impulses in the brain.81 Antiepileptic medications, like Lamictal and valproic acid, raise GABA levels
Accessed February 25, 2026.
